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辉瑞挥舞支票杀回减肥药市场 据称拟斥资73亿美元收购Metsera_蜘蛛资讯网

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总价值达到73亿美元。与上周五收盘价33.32美元相比,首付价格溢价达到42.55%,加上里程碑付款溢价将达到110%。截至发稿,今年刚上市的Metsera夜盘前涨超23%,报41.31美元。众所周知,辉瑞自研的GLP-1候选药danuglipron年初时因为耐受性(疑似肝毒性)问题被迫中止,随后又在8月放弃GLP-1R激动剂PF-06954522的开发。自研管线接连受挫后,通过收购来填补减肥药管

RA+长效胰淀素+口服减肥药”的缺口。Metsera在研管线中进展最快的是已经进入Ⅱb阶段的GLP-1 RA药物MET-097i。在一项为期12周的Ⅱ期试验中,受试者体重减少了11.3%,且副作用有限。公司正在测试将其开发为长效月注射剂,有望增加患者的依从度。Metsera管线中还有一款长效胰淀素(Amylin)类似物药物MET-233i,预计会在年底前公布更多临床数据。科学家和投资者正在期待胰淀

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